SAN FRANCISCO — Frank Gore kept an eye on the scoreboard as he ran like mad, making sure nobody caught him on the way to the end zone.

And it wasn't even close.

"Yeah, I was looking up there," Gore said with a grin of his regular practice. "I ran all day."

Gore's spectacular afternoon single-handedly re-established the run game for San Francisco.

Gore had touchdown runs of 79 and a career-best 80 yards and finished with 207 yards on 16 carries, and the 49ers beat the Seattle Seahawks, 23-10, yesterday to take an early hold atop the NFC West standings.

"I told myself, 'I'm not looking back,' " Gore said. "I told myself: 'Hey, if they're going to catch me, they're going to catch me. I'm just going to look straight ahead.' "

Gore, who surpassed San Francisco's Week 1 rushing total of 21 yards in the first series, nearly reached his franchise mark of 212 yards set in 2006 before leaving the game in the fourth quarter with a sprained right ankle that wasn't considered serious. He became only the second player in NFL history to have two TD runs of 79 or more yards in the same game, joining Barry Sanders. Sanders had runs of 80 and 82 yards at Tampa Bay on Oct. 12, 1997.

"Hey, I'm happy. I didn't know that," Gore said. "We're 2-0 in our division. We proved to a lot of people we're getting better and better."

Seattle (1-1), coming off a 28-0 season-opening win at St. Louis, took a big blow losing quarterback Matt Hasselbeck to a rib injury just before halftime following a hard hit near the goal line by Patrick Willis. Hasselbeck didn't return after completing 10 of 18 passes for 97 yards and no touchdowns.

Hasselbeck rejoined his teammates for the 2-hour flight home.

Gore also posted just the third 200-yard rushing game in team history. Charlie Garner ran for 201 yards at Dallas on Sept. 24, 2000. Gore had his 212-yard day Nov. 19, 2006, also at Candlestick Park against Seattle. His 246 total yards from scrimmage yesterday were a career high, topping the 238 he had in that '06 game with the Seahawks.

"I don't think I've ever seen anything like that," said quarterback Shaun Hill, who was 19 for 26 for 144 yards for San Francisco. "He was moving."

Joe Nedney kicked field goals of 37, 42 and 39 yards for the 49ers. Coach Mike Singletary's team is off to a 2-0 start after he demanded that his players perform better this week and find their identity as a running team.

San Francisco won at defending NFC champion Arizona in Week 1.

The 49ers' defense was dominant again this week, handing former 49ers defensive coordinator Jim Mora his first loss since taking over this season for Mike Holmgren.

"For us it's too early to tell anything," Singletary said. "Last week was ugly, but I loved it. This week was ugly, but I loved it."