INDIANAPOLIS — All-Pro safety Bob Sanders could miss four to six weeks with a high ankle sprain sustained during the Indianapolis Colts' win last Sunday over Minnesota.

Team president Bill Polian said during a taping of his weekly TV show Tuesday night that the league's defensive player of the year could also have arthroscopic "cleanup" surgery on one of his knees while he's recovering from the ankle injury.

"He will be back, that is for sure," Polian told WISH-TV. "At this point we are not sure of the severity, but four to six is the reasonable assumption at this time."

Sanders hurt his right ankle during the second half of Sunday's 18-15 win over Minnesota, adding his name to a growing list of injured Colts players.

Pro Bowl center Jeff Saturday hasn't been in a game since hurting a knee ligament Aug. 24, while starting left guard Ryan Lilja remains out after undergoing offseason knee surgery. Mike Pollak, a second-round draft choice expected to start at right guard, has been out since Aug. 24 with his own knee injury. And left tackle Tony Ugoh left Sunday's game with a groin injury.

Tight end Dallas Clark (knee) also missed the Minnesota game.